Healthcare professional surveys to investigate the implementation of the isotretinoin Pregnancy Prevention Programme: a descriptive study

作者：Crijns Ineke^*; Mantel Teeuwisse Aukje; Bloemberg Rudi; Pinas Eldridge; Straus Sabine; de Jong van den Berg Lolkje

来源：Expert Opinion on Drug Safety, 2013, 12(1): 29-38.

DOI：10.1517/14740338.2013.745850

• acne
• dermatology
• isotretinoin
• pregnancy
• prevention
• surveys

Objective: Three online surveys explored compliance with the PPP by pharmacists and dermatologists, in the Netherlands. In 2007 and 2011, two pharmacist surveys were conducted to assess improvement over time. %26lt;br%26gt;Methods: In 2007, survey was sent to members of the Utrecht Pharmacy Panel for Education %26 Research (UPPER) network (n = 1000) and in 2011, to the research group of the Dutch Association of Pharmacists (KNMP) (n = 556). In 2010, a survey was sent to 564 dermatologists of the Dutch Association of Dermatology and Venereology (NVDV). %26lt;br%26gt;Results: Both pharmacists%26apos; questionnaires had response rates of 20% and the dermatologist questionnaire of 28%. Pharmacists%26apos; checks on 30-day dispensing remained 82%, but a check whether the prescription is out-of-date decreased (61 to 53%). Pharmacists asked the patient for a negative pregnancy test in 15%, but use of contraception was checked by 44 - 49%. One hundred and five dermatologists (64%) always prescribe contraception; 35 (22%) occasionally. Ninety-three percent of the dermatologists were of the opinion that they performed the PPP. Analysis of different elements of the PPP showed that 41 (25%) were compliant. %26lt;br%26gt;Conclusions: The observed non-adherence to the isotretinoin PPP calls for careful evaluation of risk minimisation plans and participation of all stakeholders in the development of these plans.

• 出版日期2013-1