Application of Cox Model in Coagulation Function in Patients with Primary Liver Cancer

作者：Guo Xuan; Chen Mingwei^*; Ding Li; Zhao Shan; Wang Yuefei; Kang Qinjiong; Liu Yi

来源：Hepato-Gastroenterology, 2011, 58(106): 326-330.

• Cox proportional hazard model
• Coagulation function
• Primary liver cancer
• Liver cancer staging

Background/Aims: To analyze the distribution of coagulation parameters in patients with primary liver cancer; explore the relationship between clinical staging, survival, and coagulation parameters by using Cox proportional hazard model; and provide a parameter for clinical management and prognosis.
Methodology: Coagulation parameters were evaluated in 228 patients with primary liver cancer, 52 patients with common liver disease, and 52 normal healthy controls. The relationship between primary liver cancer staging and coagulation parameters was analyzed. Follow-up examinations were performed. The Cox proportional hazard model was used to analyze the relationship between coagulation parameters and survival.
Results: The changes in the coagulation parameters in patients with primary liver cancer were significantly different from those in normal controls. The effect of the disease on coagulation function became more obvious as the severity of liver cancer increased (p<0.05). The levels of D-dimer, fibrinogen degradation products (FDP), fibrinogen (FIB), and platelets (PLT) were negatively correlated with the long-term survival of patients with advanced liver cancer.
Conclusions: The stages of primary liver cancer are associated with coagulation parameters. Coagulation parameters are related to survival and risk factors. Monitoring of coagulation parameters may help ensure better surveillance and treatment for liver cancer patients.

• 出版日期2011-4
• 单位西安交通大学