Application of fast sensors to microscope mode spatial imaging mass spectrometry

作者：Brouard M^*; Johnsen A J; Nomerotski A; Slater C S; Vallance C; Yuen W H

来源：Journal of Instrumentation, 2011, 6(01): C01044.

DOI：10.1088/1748-0221/6/01/C01044

• Pixelated detectors and associated VLSI electronics
• Instrumentation and methods for time-of-flight (TOF) spectroscopy
• Mass spectrometers

The application of fast detectors to microscope mode spatial imaging mass spectrometry, in which the two-dimensional distributions of particular ion masses over a sample are projected onto a two-dimensional detector, allows the imaging of all mass peaks desorbed from a sample on each time-of-flight cycle. Detecting all fragments per duty cycle means that fewer ionisation and acquisition cycles are required for a full set of data, leading to a reduction in overall detection time, amount of sample required, and sample degradation. Results from a proof-of-concept experiment, in which a fast frame transfer charge-coupled device camera (CCD) with 10 ns time resolution was coupled to a modified velocity-mapped imaging apparatus, are presented.

• 出版日期2011-1