Accuracy of different methods for susceptibility testing of gentamicin with KPC carbapenemase-producing Klebsiella pneumoniae

作者：Arena Fabio; Giani Tommaso; Vaggelli Guendalina; Terenzi Giovanni; Pecile Patrizia; Rossolini Gian Maria^*

来源：Diagnostic Microbiology and Infectious Disease, 2015, 81(2): 132-134.

DOI：10.1016/j.diagmicrobio.2014.10.011

• Carbapenem-resistant
• Klebsiella pneumoniae
• Aminoglycosides
• Automated system
• Vitek2
• Etest
• Broth microdilution

Performance of Vitek2, Etest, and TREK broth microdilution (BMD) panels was evaluated versus reference CLSI BMD for gentamicin susceptibility testing with 57 bloodstream isolates of KPC-producing Klebsiella pneumoniae. Compared with reference BMD, the Essential Agreement and Categorical Agreement for TREK panels, Vitek2, and Etest were 91.2%, 31.6%, and 61.4%, respectively, and 86%, 21%, and 52.6%, respectively. Four very major discrepancies occurred with Vitek2. In these 4 strains, gentamicin resistance was associated with the presence of an armA aminoglycoside resistance determinant.

• 出版日期2015-2