Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle

作者：Kim H; Lee S K; Hong M W; Park S R; Lee Y S; Kim J W; Lee H K; Jeong D K; Song Y H; Lee S J^*

来源：Animal Genetics, 2013, 44(6): 750-753.

DOI：10.1111/age.12055

• AKIRIN2 gene
• longissimus muscle area
• marbling score
• single nucleotide polymorphism

The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor-kappa B (NF-B), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G%26gt;A SNP DNA marker in the 3-UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G%26gt;A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P%26lt;0.05), and marbling score (Bonferroni corrected P%26lt;0.01). These results suggest that the c.*188G%26gt;A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.

• 出版日期2013-12