2,6-Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure-Activity Relationships

作者：Straniero Valentina; Zanotto Carlo; Straniero Letizia; Casiraghi Andrea; Duga Stefano; Radaelli Antonia; Morghen Carlo De Giuli; Valoti Ermanno

来源：ChemMedChem, 2017, 12(16): 1303-1318.

DOI：10.1002/cmdc.201700201

• 2
• 6-difluorobenzamides
• antibiotics
• antimicrobial resistance
• FtsZ
• inhibitors
• MRSA

Abstract(#br)A wide variety of drug‐resistant microorganisms are continuously emerging, restricting the therapeutic options for common bacterial infections. Antimicrobial agents that were originally potent are now no longer helpful, due to their weak or null activity toward these antibiotic‐resistan...

• 出版日期2017-8-22