Dramatically Promoted Swelling of a Hydrogel by Pillar[6]arene-Ferrocene Complexation with Multistimuli Responsiveness

作者：Ni, Mengfei; Zhang, Ning; Xia, Wei; Wu, Xuan; Yao, Chenhao; Liu, Xin; Hu, Xiao-Yu; Lin, Chen^*; Wang, Leyong^*

来源：Journal of the American Chemical Society, 2016, 138(20): 6643-6649.

DOI：10.1021/jacs.6b03296

• HOST-GUEST INTERACTIONS
• EXPANSION-CONTRACTION
• MOLECULAR RECOGNITION
• DRUG-DELIVERY
• WATER
• CYCLODEXTRIN
• GEL
• POLYMERIZATION
• POLYMERS
• ADHESION

The swelling shrinking transition of hydrogels is crucial for their wide applications such as actuators and drug delivery. We hereby fabricated a smart hydrogel with ferrocene groups on pendant of polymer networks. While it was immersed in the water-soluble pillar[6]arene (WP6) aqueous solution, the hydrogel was dramatically swollen, which was an approximately 11-fold promotion in weight compared with that in pure water, due to the formation of the inclusion complexes between WP6 and ferrocene groups in the hydrogel. In particular, the well-swollen hydrogel exhibited good responsiveness to multistimuli including temperature, pH, redox, and competitive guests by tuning the dissociation/formation of WP6 ferrocene inclusion complexes or the strength of their charges. Meanwhile, potential application of such a smart hydrogel in pH-responsive drug release was demonstrated as well.

• 出版日期2016-5-25
• 单位南京大学