An intracellular buildup reaction of active siRNA species from short RNA fragments

作者：Maruyama Hideto; Nakashima Yuko; Shuto Satoshi; Matsuda Akira; Ito Yoshihiro^*; Abe Hiroshi

来源：Chemical Communications, 2014, 50(11): 1284-1287.

DOI：10.1039/c3cc47529h

Here we report a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods.

• 出版日期2014
• 单位RIKEN