An Entry to Curcuphenol/Elvirol Core Structures via a retro-Aldol Reaction

作者:Plano Maria F; Labadie Guillermo R; Jacob Melissa R; Tekwani Babu L; Cravero Raquel M*
来源:Chemistry and Biodiversity, 2011, 8(6): 1098-1111.
DOI:10.1002/cbdv.201000160

摘要

Analogs of curcuphenol/elvirol, naturally occurring bisabolane sesquiterpenes, were prepared in six steps from alkyl-alpha-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a, 6b, 6d, and 6g are also reported.

  • 出版日期2011-6