Alternations of Heart Rate Variability at Lower Altitude in the Predication of Trekkers With Acute Mountain Sickness at High Altitude

作者：Huang Hsien Hao; Tseng Chia Ying; Fan Ju Sing; Yen David Hung Tsang^*; Kao Wei Fong; Chang Shi Chuan; Kuo Terry B J; Huang Chun I; Lee Chen Hsen

来源：Clinical Journal of Sport Medicine, 2010, 20(1): 58-63.

DOI：10.1097/JSM.0b013e3181cae6ba

• acute mountain sickness
• autonomic nerve system
• heart rate varability
• hypoxia

Objective: To determine the change and relationship of spectral components of heart rate variability (HRV) measurements in subjects with or without acute mountain sickness (AMS) at both low and high altitude.
Design: A prospective study
Setting: A 12-day itinerary by trekking to the Namche Bazaar, 3440 m in Nepal.
Participants: A total of 32 subjects were recruited.
Interventions: The alternations were measured by heart rate (HR), arterial oxygen saturation (SpO(2)), and spectral analysis of HRV at sea level, 1317 m, 3440 m, 1317 in, and sea level, respectively. Main Outcome Measures: Spectral analysis of HRV
Results: There were statistically significant increases in HR and decreases in SpO(2) in all subjects at high altitude. In HRV, the values of R-R. interval, total variance, high frequency (HF), low frequency (LF), and HF% were significantly lower at 3440 m than at sea level, respectively (P < 0.05). The subjects with AMS had significantly lower total variance, HF, and HF%, respectively, but higher LF:HF ratio (P < 0.05) at 3440 m. Subjects with both HF% < 20% (nu) and LF:HF ratio > 1.3 measured at 1317 m had odds ratios of 7.00 (95% confidence interval, 1.11 to 44.06; P = 0.047) to get AMS at 3440 in.
Conclusions: The HRV measurements in total variances, HF, and 1-117% in trekkers with AMS were statistically significantly lower at high altitude. HF% < 20% (nu) or LF:HF ratio > 1.3 at lower altitudes could be an important predication parameter of trekkers with AMS at higher altitudes.

• 出版日期2010-1
• 单位中国医科大学