Modified siRNAs for the study of the PAZ domain

作者：Somoza Alvaro^*; Terrazas Montserrat; Eritja Ramon

来源：Chemical Communications, 2010, 46(24): 4270-4272.

DOI：10.1039/c003221b

Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

• 出版日期2010