A Marked Decrease in CD4-positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-associated Aplastic Anemia

作者：Ikeda Takahiro; Morimoto Akira^*; Nakamura Sachie; Yokoyama Koji; Hayase Tomomi; Oh Yukiko; Kashii Yoshifumi; Yotsumoto Shigeru; Okamoto Hiroaki; Momoi Mariko Y

来源：Journal of Pediatric Hematology/Oncology, 2012, 34(5): 375-377.

DOI：10.1097/MPH.0b013e31822bf699

• hepatitis
• aplastic anemia
• CD4/8 ratio
• lymphocyte subset
• TTV

A 10-year-old Japanese boy developed acute hepatitis with high levels of serum Torque teno virus DNA and marked lymphocytopenia, especially CD4(+) T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was largely because of a marked rise in CD8(+) cells. In contrast, CD4(+) cells recovered poorly, resulting in a further striking fall in the CD4/8 ratio. Two months later, the patient developed hepatitis-associated aplastic anemia. He was successfully treated with immunosuppressive therapy, which normalized the lymphocyte subset proportions. T-cell subsets analysis at the onset of hepatitis might be useful for predicting development of hepatitis-associated aplastic anemia.

• 出版日期2012-7