A Concise Total Synthesis of (-)-Maoecrystal Z

作者：Cha Jacob Y; Yeoman John T S; Reisman Sarah E^*

来源：Journal of the American Chemical Society, 2011, 133(38): 14964-14967.

DOI：10.1021/ja2073356

The first total synthesis of (-)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm(II)-mediated reductive cascade cydization reaction. These transformations enabled the preparation of (-)-maoecrystal Z in only 12 steps from (-)-gamma-cyclogeraniol.

• 出版日期2011-9-28