AKT as Locus of Cancer Positive Loops Conversion and Chemotherapy

作者：Radisavljevic Ziv^*

来源：Critical Reviews in Eukaryotic Gene Expression, 2015, 25(3): 199-202.

DOI：10.1615/CritRevEukaryotGeneExpr.2015013838

• AKT locus
• positive loops conversion
• locus chemotherapy
• solid cancers
• hematological malignancy

A cancer positive-feedback loops conversion is the phenomenon and principal mechanism for AKT locus chemotherapy. Such chemotherapy is the approach to target cancer robustness and complexity through the AKT signaling locus. The hypoxic cancer microenvironment generates a powerful signaling interactome with positive-feedback loops that generates cancer robustness through the AKT locus. This complexity and robustness can be successfully halted in leukemia, lymphoma, myeloma, plasmocytoma, sarcoma, and carcinoma by converting cancer positive-feedback loops into negative-feedback loops, achieved through the AKT dephosphorylation by redox balancing change. The hyperphosphorylated AKT locus is down-regulated completely to AKT dephosphorylation by redox balancing change, causing conversion of positive-feedback loops and the disappearance of malignant robustness as a direct effect of AKT locus chemotherapy.

• 出版日期2015