An easy route for the synthesis of pyrazine-2,3-dicarbonitrile 5,6-bis-substituted derivatives using a palladium catalyst

作者：Ali Hasrat; van Lier Johan E^*

来源：Tetrahedron Letters, 2012, 53(36): 4824-4827.

DOI：10.1016/j.tetlet.2012.06.102

• 5,6-Disubstituted-2,3-pyrazine
• Porphyrazines
• Pd-catalyst cross coupling reaction
• PDT
• Phthalocyanines

An easy synthetic method for the preparation of pyrazine-2,3-dicarbonitrile 5,6-bis-substituted derivatives using Pd-catalyzed cross coupling reaction (Sonogashira, Suzuki, Heck) is described. The reaction conditions allow preparing symmetrical and unsymmetrical bis-substituted products in moderate to high yields, as precursors for the preparation of highly substituted symmetrical and non-symmetrical aza-phthalocyanines with well-defined spectral properties.

• 出版日期2012-9-5