Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature

作者：Giridharan Nisha; Patel Smruti K; Ojugbeli Amanda; Nouri Aria; Shirani Peyman; Grossman Aaron W; Cheng Joseph; Zuccareiio Mario; Prestigiacomo Charies J^*

来源：Neurosurgical Focus, 2018, 45(1): E10.

DOI：10.3171/2018.4.FOCUS18100

• idiopathic intracranial hypertension
• benign intracranial hypertension
• pseudotumor cerebri
• venous sinus stenting
• CSF diversion
• optic nerve sheath fenestration

Idiopathic intracranial hypertension (IIH) is a disease defined by elevated intracranial pressure without established etiology. Although there is now consensus on the definition of the disorder, its complex pathophysiology remains elusive. The most common clinical symptoms of IIH include headache and visual complaints. Many current theories regarding the etiology of IIH focus on increased secretion or decreased absorption of cerebrospinal fluid (CSF) and on cerebral venous outflow obstruction due to venous sinus stenosis. In addition, it has been postulated that obesity plays a role, given its prevalence in this population of patients. Several treatments, including optic nerve sheath fenestration, CSF diversion with ventriculoperitoneal or lumboperitoneal shunts, and more recently venous sinus stenting, have been described for medically refractory IIH. Despite the availability of these treatments, no guidelines or standard management algorithms exist for the treatment of this disorder. In this paper, the authors provide a review of the literature on IIH, its clinical presentation, pathophysiology, and evidence supporting treatment strategies, with a specific focus on the role of venous sinus stenting.

• 出版日期2018-7