An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones Catalyzed by Iron(III) Chloride

作者：Mekala Ramamohan; Akula Raghunadh; Kamaraju Raghavendra Rao; Bannoth Chandrasekhar Kothapalli; Regati Sridhar; Sarva Jayaprakash^*

来源：Synlett, 2014, 25(6): 821-826.

DOI：10.1055/s-0033-1340786

• heterocycles
• polycycles
• ketones
• catalysis
• iron
• quinazolinones

A simple and highly efficient synthesis of 2-substituted quinazolin-4(3H)-ones by the iron(III) chloride catalyzed reaction of isatoic anhydride with various amidoxime derivatives was developed. Several aryl and alkyl amidoximes were screened to demonstrate the scope of the methodology.

• 出版日期2014-4