A single institution experience on 314 newly diagnosed advanced Hodgkin lymphoma patients: the role of ABVD in daily practice

作者：Andjelic Bosko^*; Antic Darko; Jakovic Ljubomir; Todorovic Milena; Bogdanovic Andrija; Djurasinovic Vladislava; Bila Jelena; Mihaljevic Biljana

来源：European Journal of Haematology, 2014, 93(5): 392-399.

DOI：10.1111/ejh.12364

• advanced Hodgkin lymphoma
• ABVD
• daily practice

Based on the results of clinical trials, there is no global consensus on the optimal first-line therapy for patients with advanced Hodgkin lymphoma (HL) with both ABVD and BEACOPP currently being used. However, the results of clinical trials are usually better than those in daily practice. We thus describe here our experience on 314 advanced classical HL patients treated with ABVD at the Clinical Center of Serbia and associated centers between 1997 and 2008. The median follow-up for all patients was 91months; the estimated 5-yr event-free survival was 62% and the 5-yr overall survival (OS) 76%. Multivariate Cox regression analysis revealed that patients with IPS3 and extranodal disease involving more than one site have a poorer outcome. The data presented here show on overall improvement in outcome as compared to more previous data and illustrate the problems of treating advanced stage HL outside the setting of a clinical trial.

• 出版日期2014-11