Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging

作者：Guo Y^*; Cai YQ; Cai ZL; Gao YG; An NY; Ma L; Mahankali S; Gao JH

来源：Journal of Magnetic Resonance Imaging, 2002, 16(2): 172-178.

DOI：10.1002/jmri.10140

• breast neoplasm, diagnosis
• magnetic resonance (MR)
• diffusion-weighted imaging
• apparent diffusion coefficient
• tumor cellularity
• pathology

Purpose: To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions.
Materials and Methods: Fifty-two female subjects (mean age 58 years, age range = 25-75 years) with histopathologically proven breast lesions underwent DWI of the breasts, with a single-shot echo-planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated.
Results: The ADCs varied substantially between benign breast lesions ((1.57 +/- 0.23) x 10(-3) mm(2)/second) and malignant breast lesions ((0.97 +/- 0.20) x 10(-3) mm(2)/second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P < 0.01, r = -0.542).
Conclusion: The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors.

• 出版日期2002-8
• 单位中国人民解放军海军总医院; 中国人民解放军总医院