Deep-Brain Stimulation for Aggressive and Disruptive Behavior

作者：Franzini Angelo; Broggi Giovanni; Cordella Roberto; Dones Ivano; Messina Giuseppe^*

来源：World Neurosurgery, 2013, 80(3-4): S29.e11-S29.e14.

DOI：10.1016/j.wneu.2012.06.038

• Aggressive behavior
• Deep brain stimulation
• Posterior hypothalamus

OBJECTIVE: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment.
METHODS: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording.
RESULTS: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management.
CONCLUSIONS: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.

• 出版日期2013-10