Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study

作者:Roleira F M F*; da Silva E J Tavares; Carvalho Rui A; Marques M P M
来源:Letters in Drug Design and Discovery, 2010, 7(8): 610-617.
DOI:10.2174/157018010792062731

摘要

Two lithocholic acid (LCA) derivatives - mono- and diesters (newly synthetised) - are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.

  • 出版日期2010-10