Design and synthesis of novel isoxazole-based HDAC inhibitors

作者：Conti Paola^*; Tamborini Lucia; Pinto Andrea; Sola Laura; Ettari Roberta; Mercurio Ciro; De Micheli Carlo

来源：European Journal of Medicinal Chemistry, 2010, 45(9): 4331-4338.

DOI：10.1016/j.ejmech.2010.06.035

• Histone deacetylase
• Isoxazole
• Zinc binding group
• 1,3-Dipolar cycloaddition
• Enzyme inhibition

A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn(2+)-binding group in order to check its participation in the coordinating process.

• 出版日期2010-9