Natural neurotrophic IgG autoantibodies in the blood serum of patients with different clinical outcomes after ischemic stroke

作者：Alferova V V^*; Guekht A B; Poletaev A B; Abrosimova A A; Belikova L P; Chumakova A A; Nikolaeva T Y A; Gusev E I

来源：Zhurnal Nevrologii i Psikhiatrii Imeni S S Korsakova, 2008, 108(1): 56-60.

• ischemic stroke
• clinical outcomes
• immunological reactivity
• natural autoantibodies

Recent studies revealed a role of natural neurotrophic IgG autoantibodies (NNAA) in the trophic supply of nervous tissue and modification ability of neuronal networks. Changes of the NNAA level likely may reflect direction (compensation, decompensation) of cytochemical and morphologic alterations of nervous tissue in acute focal ischemia, thus, having certain prognostic value. To assess the dynamics of NNAA in the blood serum on 3,. 7, 14 and 21 days after ischemic stroke and 3 months after the disease, 84 patients (mean age 68 10 years) with first-ever stroke in the system of internal carotid artery were studied. NNAA immunoreactivity to four nervous tissue proteins, S100 beta, GRAP, MP-65, NGF, was conducted using ELIZA method. Patients' outcomes were assessed with the Barthel Index and NIH on the 3(rd) month of the disease. in the acute period of stroke, the changes of immunoreactivity, comparing to controls, were found in 95% o cases (p<0,01), the level of NNAA pathologically increased or decreased. The increase of NNAA level was revealed in 45 patients (56% cases) with satisfactory clinical rehabilitation on 7-14 days (p<0,0001) with the following normalization of these parameters to the 21(st) day. In case of unfavorable outcomes, the prolonged increase of the NNAA level or decrease of immunoreactivity (p<0,0001) was found in 44% of cases. The changes of NNAA level were observed in 60 patients on the 3(rd) month of the disease, i.e. the protracted decrease of immunoreactivity was found in 42 patients and increase - in 18 cases (p<0,01). The quantitative changes of NNAA likely indicate the adaptive-compensative reaction of the immune system. The character of immunoreactivity changes is related to reparative neuroplasticity and may be of prognostic value.

• 出版日期2008
• 单位河北医科大学