A simple and one-pot synthesis of 2,3,4,5-tetrasubstituted 4,5-dihydro-3H-1,4-benzodiazepines

作者：Wang, Ying; Chen, Min; Ding, Ming-Wu^*

来源：Tetrahedron, 2013, 69(43): 9056-9062.

DOI：10.1016/j.tet.2013.08.034

• 4,5-Dihydro-3H-1,4-benzodiazepine
• Ugi reaction
• Aza-Wittig reaction
• One-pot reaction
• Staudinger reaction

2,3,4,5-Tetrasubstituted 4,5-dihydro-3H-1,4-benzodiazepines were synthesized in one-pot by a new sequential Ugi 4CC/Staudinger/aza-Wittig reaction, starting from easily accessible o-azidobenzaldehyde, alpha-amino ketone hydrochloride, isocyanide and carboxylic acid.

• 出版日期2013-10-28
• 单位华中师范大学