Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats

作者：Watanabe Kamiyama Mari; Shimizu Muneshige; Kamiyama Shin^*; Taguchi Yasuki; Sone Hideyuki; Morimatsu Fumiki; Shirakawa Hitoshi; Furukawa Yuji; Komai Michio

来源：Journal of Agricultural and Food Chemistry, 2010, 58(2): 835-841.

DOI：10.1021/jf9031487

• Absorption
• collagen tripeptide
• low molecular weight collagen hydrolysate
• osteoporosis
• OVX
• SHRSP

Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight Collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [(14)C]proline (Pro group) or glcyl-[(14)C] prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CFI to ovariectornized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.

• 出版日期2010-1-27