A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles

作者:Yao Pei Yuan; Zhang Yu; Hsung Richard P*; Zhao Kang
来源:Organic Letters, 2008, 10(19): 4275-4278.
DOI:10.1021/ol801711p

摘要

A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C(sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.