The tandem beta-zipper: Modular binding of tandem domains and linear motifs

作者：Matthews Jacqueline M^*; Potts Jennifer R

来源：FEBS Letters, 2013, 587(8): 1164-1171.

DOI：10.1016/j.febslet.2013.01.002

• Short linear motif
• Tandem binding
• Tandem beta-zipper
• Binding specificity
• Protein-protein interaction

The tandem beta-zipper protein-protein binding interface involves an intrinsically disordered protein (IDP) binding two or more globular domains through beta-sheet-augmentation in a modular fashion, and represents a paradigm in IDP-mediated protein-protein interactions. While characterised tandem beta-zippers are rare, known examples are associated with diverse biological processes. A combination of their advantages (binding specificity and the ability to generate high affinity binding sites by linking multiple lower affinity motifs) and the prevalence of both tandem domains and IDPs points to the existence of many more beta-zippers in nature. The characterisation of these interactions has greatly enhanced the understanding of the biological systems involved but given their apparent tolerance to mutation, detecting other tandem beta-zipper interactions using bioinformatics may be challenging.

• 出版日期2013-4-17