A mild and efficient synthesis of bis(indolyl)methane derivatives catalyzed by monoammonium salt of 12-tungstophosphoric acid

作者：Giri B Y; Devi B L A Prabhavathi^*; Vijayalakshmi K; Prasad R B N; Lingaiah N; Prasad P S Sai

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2012, 51(12): 1731-1737.

• Indole
• bis(indolyl)methane
• aromatic aldehydes
• monoammonium salt
• 12-tungstophosphoric acid [(NH4)H2PW12O40]
• heteropolyacid

A simple, highly rapid and efficient electophilic substitution reaction of indole with various aromatic aldehydes has been carried out using 5 wt% of monoammonium salt of 12-tungstophosphoric acid [(NH4)H2PW12O40] as a solid acid catalyst in acetonitrile to afford the corresponding bis(indolyl)methanes in excellent yields (84-95%) at room temperature. The heteropolyacid-based catalyst has the advantages of simple workup procedure, water insolubility with good activity and high yielding reaction fir the synthesis of bis(indolyl)methane derivatives.

• 出版日期2012-12