Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT

作者：Park Hye Lim; Yoo Ie Ryung^*; Kim Sung Hoon; Lee Sohee

来源：Annals of Surgical Treatment and Research, 2016, 91(6): 323-326.

DOI：10.4174/astr.2016.91.6.323

• Multiple endocrine neoplasia type 1
• Parathyroid neoplasms
• Single-photon emission-computed tomography
• Technetium-99m sestamibi

The most common manifestation of multiple endocrine neoplasia type 1 (MENU is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). She underwent total parathyroidectomy with video-assisted thoracoscopic surgery on an anterior mediastinal mass. Anterior mediastinal parathyroid adenoma in MEN1 patients is rare. Precise Localization of an ectopic parathyroid gland with Tc-99m sestamibi SPECT/CT can lead to successful treatment of hyperparathyroidism. This is the first reported case in the literature of mediastinal parathyroid adenoma in MEN1 patient visualized by Tc-99m sestamibi SPECT/CT.

• 出版日期2016-12