Association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil

作者：Viegas Ana Maria; de Miranda Silvana Spindola; Haddad Joao Paulo; Ceccato Maria das Gracas; Carvalho Wania da Silva^*

来源：Revista do Instituto de Medicina Tropical de Sao Paulo, 2017, 59(0): UNSP e28.

DOI：10.1590/S1678-9946201759028

• Tuberculosis
• Antibacterials
• Comprehension

The present study aimed to assess the association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis (TB) patients using fixed-dose combination (FDC) therapy in the city of Contagem, MG, Brazil. This study used standardized questionnaires to collect data. Outcomes included cure in 77.2% (64/83), noncompliance with treatment in 20.4% (17/83), and absence of organ failure or death cases. The rate of adherence to treatment was high (71.1% - 59/83), while the level of comprehension of the treatment was insufficient for the majority of patients (72.3% - 60/83). When a greater number of medicines was used, the chance of noncompliance with treatment increased exponentially (p = 0.00 - OR 1.72). Light-skinned black patients, alcoholics and those who live with HIV/AIDS showed a significant association with noncompliance with treatment (p=0.039 - OR 3.38, p=0.002 - OR 4.68, and p=0.001 - OR 9.68, respectively). Comprehension also presented a significant association with noncompliance with treatment (p=0.01 and OR 5.76 and CI 1.49-22.29). The probability of noncompliance with treatment in the first few months was greater than in the subsequent months. This study demonstrates that if the TB patients had a better understanding of the treatment, the outcome would have been more favorable as regards a proper cure.

• 出版日期2017