Ascites predicts treatment benefit of bevacizumab in front-line therapy of advanced epithelial ovarian, fallopian tube and peritoneal cancers: An NRG Oncology/GOG study

作者：Ferriss James S; Java James J; Bookman Michael A; Fleming Gini F; Monk Bradley J; Walker Joan L; Homesley Howard D; Fowler Jeffrey; Greer Benjamin E; Boente Matthew P; Burger Robert A^*

来源：Gynecologic Oncology, 2015, 139(1): 17-22.

DOI：10.1016/j.ygyno.2015.07.103

• Bevacizumab
• Advanced epithelial ovarian cancer
• Front-line therapy
• NRG Oncology
• GOG

Objectives. Predictive factors for efficacy of bevacizumab in advanced ovarian cancer have remained elusive. We investigated ascites both as a prognostic factor and as a predictor of efficacy for bevacizumab.
Methods. Using data from COG 0218, patients receiving cytotoxic therapy plus concurrent and maintenance bevacizumab were compared to those receiving cytotoxic therapy plus placebo. The presence of ascites was determined prospectively. Chi-square and Wilcoxon-Mann-Whitney tests compared baseline variables between subgroups. Survival was estimated by Kaplan-Meier method, and Cox proportional hazard models were used to evaluate independent prognostic factors and estimate their covariate-adjusted effects on survival.
Results. Treatment arms were balanced with respect to ascites and other prognostic factors. Overall, 886 (80%) women had ascites, 221 (20%) did not. Those with ascites were more likely to have: poorer performance status (p < 0.001); serous histology (p = 0.012); higher baseline CA125 (p < 0.001); and suboptimal cytoreduction (p = 0.004). In multivariate survival analysis, ascites was prognostic of poor OS (Adjusted HR 1.22, 95% Cl 1.00-1.48, p = 0.045), but not PFS. In predictive analysis, patients without ascites treated with bevacizumab had no significant improvement in either PFS (AHR 0.81, 95% CI 0.59-1.10, p = 0.18) or OS (AHR 0.94, 95% Cl 0.65-1.36, p = 0.76). Patients with ascites treated with bevacizumab had significantly improved PFS (AHR 0.71, 95% Cl 0.62-0.81, p < 0.001) and OS (AHR 0.82, 95% CI 0.70-0.96, p = 0.014).
Conclusions. Ascites in women with advanced ovarian cancer is prognostic of poor overall survival. Ascites may predict the population of women more likely to derive long-term benefit from bevacizumab.

• 出版日期2015-10