A Chemical Small Molecule Induces Mouse Embryonic Stem Cell Differentiation into Functional Vascular Endothelial Cells via Hmbox1

作者：Han, Lei; Shao, Jing; Su, Le; Gao, Jiangang; Wang, Shengqing; Zhang, Yun; Zhang, Shangli; Zhao, Baoxiang; Miao, Junying^*

来源：Stem Cells and Development, 2012, 21(15): 2762-2769.

DOI：10.1089/scd.2012.0055

• IN-VITRO
• ANGIOGENESIS
• DERIVATIVES
• EXPRESSION
• DISCOVERY
• PROTEIN
• DESIGN
• VIVO

Embryonic stem cells (ESCs) can differentiate to endothelial progenitor cells and vascular endothelial cells (VECs), but the mechanism is largely unknown. In this study, we synthesized 2 chiral compounds (R-ABO and S-ABO) and identified R-ABO as an effective inducer of ESC differentiation into VECs. Furthermore, we found that R-ABO induced ESC differentiation into VECs via homeobox containing 1 (Hmbox1) that acted upstream of fibroblast growth factor 2 (FGF-2). The data suggest that R-ABO is a novel tool for ESC differentiation into VECs, and Hmbox1 is a key regulator in this differentiation process. These findings provide information on a novel target and a new platform for further investigating the gene control of ESC differentiation to VECs.

• 出版日期2012-10
• 单位山东大学