May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? Critical Review and Synthesis of Evidence

作者：Papathanassoglou Elizabeth D E; Miltiadous Panagiota; Karanikola Maria N

来源：Biological Research for Nursing, 2015, 17(5): 521-539.

DOI：10.1177/1099800414555411

<jats:sec><jats:title>Introduction:</jats:title><jats:p>Exercise attenuates inflammation and enhances levels of brain-derived neurotrophic factor (BDNF). Exercise also enhances parasympathetic tone, although its role in activating the cholinergic anti-inflammatory pathway is unclear. The physiological pathways of exercise’s effect on inflammation are obscure.</jats:p></jats:sec><jats:sec><jats:title>Aims:</jats:title><jats:p>To critically review the evidence on the role of BDNF in the anti-inflammatory effects of exercise and its potential involvement in the cholinergic anti-inflammatory pathway.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Critical literature review of studies published in MEDLINE, PubMed, CINAHL, Embase, and Cochrane databases.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>BDNF is critically involved in the bidirectional signaling between immune and neurosensory cells and in the regulation of parasympathetic system responses. BDNF is also intricately involved in the inflammatory response: inflammation induces BDNF production, and, in turn, BDNF exerts pro- and/or anti-inflammatory effects. Although exercise modulates BDNF and its receptors in lymphocytes, data on BDNF’s immunoregulatory/anti-inflammatory effects in relation to exercise are scarce. Moreover, BDNF increases cholinergic activity and is modulated by parasympathetic system activation. However, its involvement in the cholinergic anti-inflammatory pathway has not been investigated.</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>Converging lines of evidence implicate BDNF in exercise-mediated regulation of inflammation; however, data are insufficient to draw concrete conclusions. We suggest that there is a need to investigate BDNF as a potential modulator/mediator of the anti-inflammatory effects of exercise and of the cholinergic anti-inflammatory pathway during exercise. Such research would have implications for a wide range of inflammatory diseases and for planning targeted exercise protocols.</jats:p></jats:sec>

• 出版日期2015-10