A chiral stationary phase coated by surface molecularly imprinted polymer for separating 1,1 '-binaphthalene-2,2 '-diamine enantiomer by high performance liquid chromatography

作者：Dong, Hongxing^*; Zheng, Meixia; Ou, Yiling; Zhang, Chunhong; Liu, Lijia; Li, Junqing; Yang, Xiaoguang

来源：Journal of Chromatography A, 2015, 1376: 172-176.

DOI：10.1016/j.chroma.2014.12.009

• 1,1 '-Binaphthalene-2,2 '-diamine
• Coating
• Chiral separation
• Surface molecularly imprinted polymers

This report describes novel pathway for the development of a new type of CSP. A chiral stationary phase (CSP) prepared by coating a molecularly imprinted polymer (MIP) on the surface of silica gel (SMIP-CSP) showed a high separation factor (3.39) in separating racemic 1,1'-binaphthalene-2,2'-diamine (DABN) by high performance liquid chromatography (HPLC). Being the crosslinking agent, ethylene glycol dimethacrylate (EGDMA) was copolymerized with the monomer, methacrylic acid (MAA), in the presence of (R)-DABN as the template molecules on the surface of the silica gel particles to produce the SMIP-CSPs. The effects of the pretreatment temperature, the (R)-DABN content and the type of silica gel and monomer in the SMIP-CSPs on the separation of the racemic DABN were systematically investigated.

• 出版日期2015-1-9
• 单位哈尔滨工程大学