Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

作者：Ferrari Marco; Bolla Emilio; Bortolaso Paola^*; Callegari Camilla; Poloni Nicola; Lecchini Sergio; Vender Simone; Marino Franca; Cosentino Marco

来源：Psychiatry Research, 2012, 200(2-3): 1014-1017.

DOI：10.1016/j.psychres.2012.07.002

• Pharmacogenetic
• Schizophrenia
• Cytochrome

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).

• 出版日期2012-12-30