PAI-1 and D-Dimer in Type 2 Diabetic Women With Asymptomatic Macrovascular Disease Assessed by Carotid Doppler

作者：Soares Anna Leticia; Rosario Pedro Wesley; Ribeiro Borges Michelle Aparecida; Sousa Marinez Oliveira; Salles Moura Fernandes Ana Paula; Carvalho Maria das Gracas^*

来源：Clinical and Applied Thrombosis/Hemostasis, 2010, 16(2): 204-208.

DOI：10.1177/1076029609334626

• type 2 diabetes
• hypercoagulability
• in vitro diagnostic systems

Asymptomatic diabetic patients with different degrees of macrovascular complications can present different hemostatic changes. At this study, plasminogen activator inhibitor-1 (PAI-1) and D-dimer were evaluated in 12 women without diabetes and 64 type 2 diabetic women. All patients were classified into 3 different categories according to the carotid intima-media thickness (IMT) assessed by Doppler: 25 with <1 mm (normal), 15 with >1 mm and without plaque (intermediate), and 24 with stenosis lower than 50% of the vessel lumen (plaque). The results showed increased plasma D-dimer in type 2 diabetic women with carotid plaque when compared to the other groups. High levels of PAI-1 were observed in all the 3 groups of diabetic women when compared to women without diabetes. Our results suggest that high levels of PAI-1 in type 2 diabetic women are only associated with diabetes and are not associated with macrovascular progression; however, it seems that D-dimer plasma levels are associated with carotid plaque.

• 出版日期2010-4