A LOW-MOLECULAR-WEIGHT ALLERGEN OF WHITE BIRCH (BETULA-VERRUCOSA) IS HIGHLY HOMOLOGOUS TO HUMAN PROFILIN

作者:VALENTA R; DUCHENE M; BREITENBACH M; PETTENBURGER K; KOLLER L; RUMPOLD H; SCHEINER O; KRAFT D
来源:INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1991, 94(1-4): 368-370.

摘要

Cloning of allergens has contributed substantially to the understanding of mechanisms in allergic diseases by providing information about the sequence and hence biological functions of allergens. The major birch pollen allergen, Bet nu I [Breiteneder H, et al: EMBO J 1989;8:1935-1938] and the white-faced hornet venom allergen (antigen 5) [Si Yun Fang K, et al: Proc. Natl. Acad. Sc. USA 1988;85:895-899] were shown to be highly homologous to pathogenesis-related proteins of plants. In the case of the major allergen of house dust mite, Der p I, homology to proteases was demonstrated. Therefore, the proposed biological function of these IgE-binding proteins might be related to their allergenic potential. In this paper we tentatively identify a ubiquitous family of low molecular weight allergens as profilins. The identification is based on a

  • 出版日期1991