Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease

作者：Feitosa Marley Ribeiro^*; Feres Filho Omar; Tamaki Camila Mussolin; Perazzoli Camila; Angelete Alvarez Bernardes Mario Vinicius; Parra Rogerio Serafim; Ribeiro da Rocha Jose Joaquim; Feres Omar

来源：Acta Cirurgica Brasileira, 2016, 31(suppl 1): 19-23.

DOI：10.1590/S0102-86502016001300005

• Hyperbaric Oxygenation
• Crohn Disease
• Cutaneous Fistula
• Pyoderma Gangrenosum

PURPOSE: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease.
METHODS: A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease.
RESULTS: A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%.
CONCLUSION: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.

• 出版日期2016