Assessment of Rodents as Animal Models for Reston Ebolavirus

作者：de Wit Emmie; Munster Vincent J; Metwally Samia A; Feldmann Heinz^*

来源：Journal of Infectious Diseases, 2011, 204(suppl_3): S968-S972.

DOI：10.1093/infdis/jir330

The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-/-) mice may be used for research of REBOV pathogenicity and intervention strategies.

• 出版日期2011-11-1