Activity of lipo-cyclic gamma-AApeptides against biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa

作者：Padhee Shruti; Li Yaqiong; Cai Jianfeng^*

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(12): 2565-2569.

DOI：10.1016/j.bmcl.2015.04.039

• Biofilm prevention
• Peptidomimetics
• Antimicrobial

Antibiotic resistant bacterial infection is currently a serious public concern. Their ability to form biofilms further complicates the treatment. Herein we investigated the activity of lipo-cyclic gamma-AApeptides against both planktonic cells and biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa, in comparison to those of the conventional antibiotic ciprofloxacin. Our results suggest that these lipo-cyclic gamma-AApeptides exhibit comparable or enhanced performance compared to ciprofloxacin in the prevention of biofilm formation for both Gram-positive and Gram-negative bacteria, providing a potential alternative treatment and prevention for indwelling device-related infections.

• 出版日期2015-6-15