DUAL-MODE IVUS TRANSDUCER FOR IMAGE-GUIDED BRAIN THERAPY: PRELIMINARY EXPERIMENTS

作者：Herickhoff Carl D^*; Wilson Christy M; Grant Gerald A; Britz Gavin W; Light Edward D; Palmeri Mark L; Wolf Patrick D; Smith Stephen W

来源：Ultrasound in Medicine and Biology, 2011, 37(10): 1667-1676.

DOI：10.1016/j.ultrasmedbio.2011.06.017

• Dual-mode catheter transducer
• Ultrasound hyperthermia
• Intravascular ultrasound

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 x 0.5 x 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5 degrees C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument. (E-mail: cdh14@duke.

• 出版日期2011-10