A strategy for the synthesis of hydrophobic proteins and glycoproteins

作者:Hojo Hironobu*
来源:Organic and Biomolecular Chemistry, 2016, 14(27): 6368-6374.
DOI:10.1039/c6ob00827e

摘要

Our synthetic strategy for the hydrophobic glycoprotein is summarized. The reverse-polarity protection strategy, in which the side chain carboxy group is protected as a basic picolyl ester, combined with the O-acylisopeptide method proved to be efficient for the preparation of the hydrophobic glycoprotein by ligation methods, and would be applicable for the synthesis of membrane proteins in the future.

  • 出版日期2016