Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide

作者：Seth Kapileswar; Bera Milan; Brochetta Massimo; Agasti Soumitra; Das Ashis; Gandini Andrea; Porta Alessio; Zanoni Giuseppe^*; Maiti Debabrata^*

来源：ACS Catalysis, 2017, 7(11): 7732-7736.

DOI：10.1021/acscatal.7b02394

• C-H olefination
• palladium catalyst
• unactivated aliphatic alkene
• sequential hetero-bis-olefination
• gram-scale synthesis

The use of unbiased aliphatic alkene as the coupling partner for C-H olefination continues to be a challenging task. A suitable chelating directing group allowed ortho C-H olefination of benzyl phosphonamide with unactivated aliphatic alkenes. The broad substrate scope with respect to variation of benzyl phosphonamides and aliphatic alkenes as well as examples of sequential hetero-bis-olefinations offer diversity along with excellent linear/branch selectivity.

• 出版日期2017-11