An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

作者:Jean Alexandre; Blanchet Jerome*; Rouden Jacques; Maddaluno Jacques; De Paolis Michael
来源:Beilstein Journal of Organic Chemistry, 2013, 9: 1480-1486.
DOI:10.3762/bjoc.9.168

摘要

A concise and regioselective preparation of 2-heteroarylmethylene decorated N-arylpyrroles is described through a metal-free Mannich/Wittig/hydroamination sequence followed by isomerization of the N-arylpyrrolidine adducts. Furthermore, the C-H regioselective oxidation of these substrates is demonstrated, extending the molecular diversity and versatility of these scaffolds.

  • 出版日期2013-7-24