Anti-allergic effects of His-Ala-Gln tripeptide in vitro and in vivo

作者：Tanaka Mamoru; Watanabe Hiroyuki; Yoshimoto Yoshinobu; Kozai Hana; Okamoto Takeaki^*

来源：Bioscience Biotechnology and Biochemistry, 2017, 81(2): 380-383.

DOI：10.1080/09168451.2016.1243984

• anti-allergic effect
• peptide
• mouse model
• RBL-2H3 cell

We examined the inhibitory effects of HAQ (His-Ala-Gln) peptide on type-1 allergy in vitro and in vivo. HAQ peptide inhibited -hexosaminidase release and intracellular Ca2+ levels of rat basophilic leukemia RBL-2H3 cells. Oral administration of a HAQ peptide-added diet (1mg/mouse/administration) to C3H/HeJ mice for 14days led to significant suppression of allergic symptoms, but did not reduce allergen-specific IgE or IgG(1).

• 出版日期2017-2