A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood

作者：Tsuji Kenji; Uchida Haruhito Adam^*; Ono Tetsuichirou; Inoue Tatsuyuki; Shinagawa Katsuji; Kitamura Shinji; Maeshima Yohei; Sugiyama Hitoshi; Makino Hirofumi

来源：BMC Nephrology, 2012, 13: 46.

DOI：10.1186/1471-2369-13-46

• Hypogammaglobulinemia
• Focal segmental glomerulosclerosis
• Proteinuria

Background: Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause. %26lt;br%26gt;Case presentation: We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35 years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN. %26lt;br%26gt;Conclusion: This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.

• 出版日期2012-6-24