Bone Turnover Markers Predict Bone Mass Development in Young Adult Men: A Five-Year Longitudinal Study

作者：Darelid Anna; Nilsson Martin; Kindblom Jenny M; Mellstrom Dan; Ohlsson Claes; Lorentzon Mattias^*

来源：Journal of Clinical Endocrinology & Metabolism, 2015, 100(4): 1460-1468.

DOI：10.1210/jc.2014-3947

Context: Peak bone mass is an important factor for the lifetime risk of developing osteoporosis. Ways to predict bone development in young adulthood are lacking.
Objective and Main Outcome Measures: The aim of this study was to investigate whether baseline measurements of bone turnover markers could predict bone development in early adulthood in men.
Design, Setting, and Participants: In total, 817 men (age at baseline, 18.9 +/- 0.6 y; mean +/- SD) from the population-based Gothenburg Osteoporosis and Obesity Determinants Study were included in this 5-year longitudinal study. Areal bone mineral density (aBMD) and bone mineral content (BMC) were measured using dual-energy x-ray absorptiometry, and volumetric BMD(vBMD) and cortical bone size were measured using peripheral quantitative computed tomography. Blood samples were collected at the baseline visit, and levels of osteocalcin (OC) and N-terminal telopeptide of type I collagen were analyzed.
Results: OC was a positive predictor of the increase in aBMD and BMC of the total body (R-2: aBMD, 6.6%; BMC, 4.9%), lumbar spine (R-2: aBMD, 5.4%; BMC, 5.7%), and radius (R-2: aBMD, 14.8%; BMC, 12.8%) between 19 and 24 years (P < 001). Men in the highest OC quartile at baseline (35.2 +/- 4.4 ng/mL; mean +/- SD) gained markedly more in radius cortical cross-sectional area (4.0 +/- 4.3 vs 1.9 +/- 2.9 mm(2)) and trabecular vBMD (11 +/- 7 vs 3 +/- 12 mg/mm3) than men in the lowest OC quartile at baseline (17.7 +/- 2.3 ng/mL; mean +/- SD) (P < 001).
Conclusion: A high OC level at the age of 19 predicts a favorable development in BMD, BMC, and bone size between 19 and 24 years of age.

• 出版日期2015-4
• 单位河北医科大学