A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazoles

作者：Lemaire Lucas; Leleu Chavain Natascha; Tourteau Aurelien; Abdul Sada Alaa; Spencer John; Millet Regis^*

来源：Tetrahedron Letters, 2015, 56(19): 2448-2450.

DOI：10.1016/j.tetlet.2015.03.082

• Heterocycles
• Microwaves
• Parallel synthesis

Starting from a 5-amino-2-phenyloxazole-4-carbonitrile building block 3, obtained by reaction of benzoyl chloride (1) and aminomalononitrile p-toluenesulfonate (2), a large range of molecules were synthesized in one or two steps. A total of seven pyrimido[5,4-d]oxazoles 5(a-d)-8 and four pyrido[3,2-d]oxazoles 9-12 have been synthesized. Moreover, synthetic procedures have been adapted to overcome the instability of the oxazole ring.

• 出版日期2015-5-6