Anti-Oxidative and Anti-Inflammatory Effects of Phenolic Compounds from the Stems of Quercus acuta Thunberg

作者：Oh M H; Park K H; Kim M H; Kim H H; Kim S R; Park K J; Heo J H; Lee M W^*

来源：Asian Journal of Chemistry, 2014, 26(15): 4582-4586.

DOI：10.14233/ajchem.2014.16116

• Quercus acuta
• Phenolic compound
• DPPH
• Xanthine oxidase
• Nitric oxide

Two flavan 3-ols i.e., (+)-catechin (1), (-)-epicatechin (2)], three flavanonols i.e., [taxifolin (3), taxifolin 3-O-beta-D-glucopyranoside (4) and taxifolin 4%26apos;-O-beta-D-glucopyranoside (5), one proanthocyanidin i.e., procyanidin B-3 (6) and one i.e., neolignan (+)-lyoniresinol 3 alpha-O-beta-D-xylopyranoside (7) have been isolated from the stems of Quercus acuta Thunberg (QAS) by anti-oxidative activity-guided isolation. Although these compounds have been reported previously. To our best of knowledge, this is the first study to report their isolation from Q. acuta Thunberg. Anti-oxidative activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and superoxide dismutase (SOD)-like superoxide anion (generated by xanthine oxidase/hypoxanthine) scavenging assays. Anti-inflammatory activity was assessed by quantifying the nitric oxide in the supernatant of lipopolysaccharide (LPS)-stimulated mouse Raw 264.7 macrophage cells.

• 出版日期2014-8