A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2

作者:Xiao Yanping; Freeman Gordon J*
来源:Clinical Cancer Research, 2015, 21(10): 2201-2203.
DOI:10.1158/1078-0432.CCR-14-2658

摘要

HHLA2 is a newly identified B7 family member that modulates T-cell functions through interaction with TMIGD2 and possibly a second receptor, with coinhibition in two studies and costimulation in one study. HHLA2 is expressed on a variety of human cancers, and its coinhibitory function makes it a candidate for cancer immunotherapy.

  • 出版日期2015-5-15